Muira Puama is an indigenous name for a genus of plants, made up of 2 species, that are native to the Amazon rainforest in South America. The english botanical name for the genus is Ptychopetalum.
Ptychopetalum olacoides and Ptychopetalum uncinatum are the species that make up the genus. Although the chemical makeup of the two species is similar, Ptychopetalum olacoides has a larger concentration of active medical ingredients.
The indigenous name for medicine that is obtained from the plants is also referred to as Muira Puama. Although most parts of the plants contain active ingredient, medicine is most often produced from the bark and root of Ptychopetalum olacoides.
Muira Puama can be classified as:
--- A nootropic.
--- An anti-depressant.
--- An anti-anxiety agent.
--- A mild GABA antagonist.
--- An acetylcholinesterase inhibitor.
--- A pain reliever (binds to opioid receptors).
Muira Puama inhibits acetylcholinesterase from breaking down the neurotransmitter acetylcholine. This results in increased levels of acetylcholine. For those individuals with low levels of acetylcholine, increased levels can help improve cognition.
Muira Puama also slightly reduces the effect of the neurotransmitter GABA in the human body, it acts as a mild GABA antagonist. A GABA antagonist binds to GABA receptors and prevents GABA from triggering them.
Rather than reducing the level of GABA, the antagonist effect doesn't actually lower the amount of GABA in the human body, but it produces effects that are very similar to reducing GABA levels.
Muira Puama can:
--- Reduce pain.
--- Reduce anxiety.
--- Increase libido.
--- Improve cognition.
--- Reduce depression.
--- Treat symptoms of ADHD.
If it works for you, this is one of the better substances for improving mental process, because of the additional benefits. It won't kill pain like strong opioids, but if you have no opioid tolerance it can reduce mild to moderate pain so you are able to function.
A dose of about 250-1500 mg is a good starting point. At dose sizes in this range, many people find it can be fairly stimulating and increases their physical and mental energy levels. At the same time doses in this range are also mentally calming and relaxing.
As the dose size increases, Muira Puama tends to become more physically sedating and may result in sleep. The anti-depressant and anti-anxiety properties can also become even stronger as the dose size increases.
For a more physically energetic experience, try keeping the dose size to between 250-1500 mg. For a more physically sedating effect, most people will find that doses in the 1500-6000 mg range much more effective for this purpose.
There are some people who find doses in the 1500-2500 milligram range are enough for physical relaxation purposes while others may require up to 6000 milligrams, or even more, to produce satisfactory results.
Concentrates require smaller doses. For instance, a 4:1 extract (4 times stronger than regular powder) will only require 1/4 of what a comparable dose of regular powder would be. A 500 mg dose of 4:1 extract would equal a 2000 mg dose of regular powder.
When Muira Puama is put in capsules and washed down with a glass of water or juice, on an empty stomach, it can take up to 60-120 minutes (1-2 hours) for Muira Puama to start working and 180-240 minutes (3-4 hours) to fully kick in.
Most of the active chemicals in Muira Puama are alcohol soluble. Muira Puama can work faster when powder is mixed into a drink that contains alcohol, and held under the tongue for 30 seconds or longer before swallowing.
Alternately, the powder can be put in vegetable capsules and washed down with a drink that contains alcohol. The powder can also be prepared into an alcohol tincture. Either way it works faster when taken on an empty stomach.
An extract might be the best for larger doses. It takes about 2-3 (#00) capsules to accommodate 1000 milligrams of regular powder. Some people take 6000 milligram doses, which would take 12-18 (#00) capsules to accommodate.
Muira Puama Availability
Prior to taking Muira Puama for the first time, to be safe discuss it with your physician. On your first attempt it might be the best thing to try working with a small quantity, somewhere in the neighborhood of 250-1500 milligrams.
A small dose size will give you an indication of the possible results as well as alerting you to any negative reactions. At small dose sizes, the effects are subtle and some people might not notice anything.
May raise blood pressure.
May cause gastrointestinal problems.
Large doses and daily ingestion can cause anxiety.
It would be best to avoid combining Muira Puama with any opioid agonist (hydrocodone, morphine, oxycodone, etcetera) because of cross tolerance issues.
May slightly reduce the effects of alcohol, barbiturates, benzodiazepines, or other substances that increase GABA levels or produce effects that are similar to increasing GABA levels.