Tianeptine is a generic name for a drug that has been marketed under several brand names including Coaxil, Salymbra, Stablon, Tatinol, Tianeurax, Zinosal .
It was first synthesized by The French Society of Medical Research in the 1960s. It is presently an approved drug in some Asian, several European Union, as well as various South American nations.
In the United States and Belgium, tianeptine was at one time being studied as a treatment for major depressive disorder. Clinical trials were conducted but the studies were ceased in 2012.
Tianeptine Effects And Classification
Tianeptine can be classified as belonging to several categories of medication including:
Analgesic (reduces pain).
Anxiolytic (reduces anxiety).
Nootropic (can improve matters related to thinking).
Tricyclic antidepressant (can reduce or eliminate depression).
It can be an effective medication as a:
Treatment for ADHD.
Treatment for anhedonia.
Treatment for asthma.
Treatment for panic disorder.
Treatment for irritable bowel syndrome.
Treatment for sufferers of mood disorders.
Tianeptine is utilized as a treatment for anxiety and various anxiety related disorders including social anxiety. As well it can be effectual at treating many types of depression.
Types of depression that might respond to tianeptine include:
Major depressive disorder.
Depression related to Parkinson's disease.
Depression related to post-traumatic stress disorder.
For some men it can be employed as an effective treatment for erectile dysfunction. But, it can also have the opposite effect on other men, and cause impotence.
Tianeptine can produce feelings of well being, increase mental focus, increase alertness. It can help recovery from a hangover, if not, it will probably at least make you feel a bit better.
It offers pain reduction benefits for some individuals, and if it works for you might be a good replacement, or alternate medication, for small to moderate doses of opioid pain relievers.
You might want to try quitting opioids and using tianeptine instead, or cycling between tianeptine and opioids and reduce tolerance, and addiction potential, to both substances. However, be aware that tianeptine can be addictive.
Tianeptine is not a depressant, it does not slow the central nervous system. This means it will not decrease energy or induce lethargy, which will make it a good choice for pain sufferers who take meds to be able to work or remain active.
Unfortunately tianeptine does not produce the same level of euphoria that opioids do. It is not recommended as a recreational drug unless you are in jail or prison, or for some reason can't access real oxy, or whichever med you prefer.
For people who respond well to tianeptine, it can be a very good alternative to benzodiazepines for treating anxiety. It doesn't produce the drugged or drunk feeling that benzos do, if anything tianeptine tends to induce clear thinking.
Tianeptine may be potentiated by, or potentiate, various medications like amphetamines, benzodiazepines, cannabis products, opioids, or other substances that affect dopamine. Potentiate here means to amplify or increase the effects of.
Standard starting dose size for most applications is 12-15 milligrams, with a recommended maximum of 45 milligrams per day. When taken in a single 12-15 mg dose, you might not notice any benefit.
If you take 3 doses of 12-15 milligrams spaced at equal intervals, you could obtain better results. Some people get good results with dose levels of as low as 5 milligrams.
If there is no noticeable improvement you can slowly increase the dose size in small increments, 5 milligram increments are reasonable. Try to keep the dose size as small as possible to reduce tolerance and addictive potential, and withdrawal severity.
At lower dose levels it can induce relaxation, but it does not decrease physical energy, and may even be stimulating. Larger doses, of 50-75 milligrams or more, can be more stimulating and tend to increase physical energy.
If you ingest larger doses, it is recommended to only dose once in a day. Even at small dose levels, to avoid problems with addiction, it is best to limit intake to no more than twice a week, with 3-4 days between doses.
Tianeptine is produced in various forms. Depending on the intended application, one type or a combination of different types, might be better suited to produce optimal results.
The most often encountered forms are tianeptine sodium, tianeptine free acid, tianeptine sulfate. Tianeptine sodium is a salt. It is generally the most common form available. It's water soluble and absorbed quickly by the human body if ingested orally.
Tianeptine sodium powder will get gooey if it comes into contact with humid air. You must be sure to keep it dry and well sealed if you don't want goo. Provide a desiccant to keep close to the powder so as to absorb moisture.
If the sodium does get gooey, it is still good but can be harder to work with and weigh. Goo will solidify into clumps that might be easier to use, if it is dried.
Both tianeptine free acid and tianeptine sulfate hemihydrate are less water soluble and take longer to be absorbed by the human body. Because they are absorbed slower, effects last longer.
If you take tianeptine sodium, and either tianeptine free acid and tianeptine sulfate at the same time orally, you get a long lasting medication that starts to work quickly.
Experiment with the ratio and you can come up with an effective medicine that will last most of, or all, day. Doses that are larger than your body can tolerate will probably make you feel sick.
Like all medications, there are people who respond to it, and those who don't. If you don't feel anything at doses of 75 milligram or larger, you might best seeking another medication.
Tianeptine can be mixed with liquid, like fruit juice, and drank. It doesn't mix that well and can be bitter when prepared in this manner. In order to avoid waste and the bitter taste, it might be best to put it in a capsule and take it orally. Do so on an empty stomach for quickest results.
Possible combinations include:
Adrafinil and tianeptine.
Phenibut and tianeptine.
Phenylpiracetam and tianeptine.
Before utilizing tianeptine as a medication, to be safe discuss it with your physician. On your first attempt it might be the best thing to try working with a small quantity, somewhere in the neighborhood of 10-12 milligrams or less.
A small dose size will give you an indication of the possible results as well as alerting you to any negative reactions. At small dose sizes, the effects are subtle and some people might not notice anything.
Tianeptine Warnings, Side Effects
Tolerance and addiction can be very real issues for some individuals. Limit intake and don't consume more than once or twice a week to limit the potential. Taper off gradually if you have been taking it daily for a while.
Common side effects include: agitation, anxiety, constipation, dizziness, drowsiness, dry mouth, headache, insomnia, irritability, nausea, nightmares, stomach pain, weight gain.
Less common side effects include: bad taste, bladder disturbances, heart palpitations, hot flashes, impaired vision, muscle aches, passing of gas, postural hypotension (low blood pressure that occurs when you stand), premature ventricular contractions (extra abnormal heartbeats), tremor.
Even less common than the less common side effects are: allergic skin reactions, changes in electrocardiogram readings, hypomania, inflammation of the liver, long lasting muscle aches, severe itching.
Avoid tianeptine if you have taken large doses of any form of MAOI in the previous two weeks. If not, there is a chance of cardiovascular problems, convulsions, high body temperature, death. Tianeptine is not recommended for people under 15 years of age.
Tianeptine can be hard on the liver. Make sure your physician knows you intend to take this medication if have a history of liver related problems. Come down can be hard for recreational users after it wears off, especially large doses.
Erowid tianeptine reports.
Wikipedia tianeptine page.